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A diagnosis of pancreatic cancer is devastating news. Though it makes up only about 3% of cancers in the United States, it’s one of the deadliest, and on track for a dark achievement: By 2030, it’s expected to kill more people in the United States than any cancer except for lung cancer. This apparent paradox is rising because screening and treatments for other cancers have surged ahead, while pancreatic cancer has remained tricky both to identify and to treat, Knowable Magazine reports.

Nonetheless, there’s reason for hope, says Anna Berkenblit, chief scientific and medical officer for the Pancreatic Cancer Action Network in El Segundo, California, which supports research and helps patients. Scientists are testing new medicines that disable drivers of cancer that were once considered undruggable. They’re training patients’ immune systems to attack tumors once thought to be invisible to the body’s defenses. And they’re harnessing artificial intelligence to catch pancreatic cancer in early, vulnerable stages.

“The goal is to transform pancreatic cancer into a curable disease,” says Andrew Rakeman, vice president of research for the Lustgarten Foundation on Long Island, New York, which supports science on pancreatic cancer. Or, at least, “something that’s survivable, and livable, and can become more of a chronic condition.”

The five-year survival rate for pancreatic cancer is a dismal 13%. That’s partly because pancreatic tumors surround themselves in dense, scar-like tissue, blocking medicines and immune cells. Small tumors advance quickly but often go unnoticed until they’ve spread, making it too late for surgeons to remove all the cancer.

One of the biggest hopes right now is medicines that target a protein called KRAS, which is part of a cell’s growth-control machinery. In more than 90% of pancreatic cancers, mutated versions of KRAS get stuck in the “on” position, so cells divide uncontrollably.

Cancer biologists would love to shove a stick into the machinery of KRAS, but they’ve struggled to find a place to jam that stick. “People have described it to me as like a small, greasy ball … there’s no kind of pocket to stick an inhibitor in,” says cancer biologist Paige Ferguson of the Cold Spring Harbor Laboratory in New York, who cowrote an article about the challenges of treating pancreatic cancer in the 2025 Annual Review of Cancer Biology.

So researchers took a different tack: They were able to design a drug that attaches to a different cell protein. That drug/protein duo then grabs KRAS, stifling its dirty work. In an early trial, 38 people with pancreatic cancer receiving the drug, daraxonrasib, survived for more than eight months, on average, wit

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Not to unduly alarm homeowners out there, but it’s of vital importance for you to know that your water … could explode. Sorry to alarm you, but it’s true. Your water heater is a dependable workhorse home system that provides your plumbing fixtures with a steady supply of hot water in all seasons. But when things go wrong with your water heater, they could really go wrong — occasionally with explosive results.

Not to blow things out of proportion, as the phenomenon is relatively uncommon — especially with modern units, which have improved failsafe mechanisms — and the chances are minuscule that you’d get rocket-like liftoff through your roof like in an episode of TV’s “MythBusters” back in 2007 — but a water heater explosion poses great danger, so knowing how to ensure yours doesn’t become a ticking time bomb is a must, HomeServe reports.

Can a Water Heater Explode?

The risk of a water heater explosion rises if you don’t maintain your unit correctly or ignore common warning signs. Generally, water heater explosions occur when the temperature inside your water heater exceeds the safe limit, increasing the pressure inside the tank and potentially causing it to burst.

How Do Water Heater Explosions Happen?

During a water heater explosion, your unit likely will release significant quantities of scalding water and steam into your home. An explosion can cause serious injuries, such as burns, to anyone near the unit.

Injuries aren’t the only potential hazard of a burst water heater. Water released from the tank can cause severe damage to floors, walls and other elements of your home. The force of the explosion may also damage your furnishings and personal belongings.

Gas water heater explosions can be particularly dangerous because they could damage the gas line supplying the unit, leading to a gas leak. Gas leaks increase the risk of house fires and can cause physical symptoms such as lightheadedness and nausea.

What Causes Water Heater Explosions?

The most common cause of a water heater blowing up is rust inside the unit. Rust prevents water and heat from circulating through your system properly, leading to pressure buildup. Installing your water heater incorrectly can also cause pressure problems and increase the risk of an explosion — so hiring a professional plumber to install a new water heater is essential.

Rust inside your water heater is challenging for a layperson to diagnose, but some common warning signs could indicate a buildup of rust and sediment inside your system. You can reduce the risk of a water heater explosion by scheduling a checkup with a qualified professional whenever you notice one or more of the following issues:

• Leaking or constantly open pressure release valve
• Hissing, banging or clanking noises coming from the water heater
• Discolored water
• Unpleasant, rotten egg smells coming from your water heater or fixtures

How to Prevent Water Heater Explosions

Hiring a pro to inspect and clean your water heater at least once a year

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It might sound like an old wives’ tale, but women do indeed live longer than men. It’s actually the case for the majority of mammals in the animal kingdom. This is nothing new: The female species has enjoyed a longevity edge since researchers started reporting these statistics.

What’s interesting about this fact is that historically, women have had to deal with more illness and difficult life conditions, like poverty and having less control in their lives and more limited access to resources. And research suggests that while their years on the planet may be longer, they are filled with more age-related illnesses and overall “dings” to their well-being—giving men an advantage for overall healthspan.

Why this paradox? The answers aren’t totally clear. Life Extension reviews what is known, though, and how blood testing and lifestyle changes can help men close the gap and get the most from their golden years.

At a glance

• Globally, women live about 5.4 years longer than men on average.
• The longevity gap likely stems from a combination of biological factors and behavioral differences between the sexes.
• Even though they live longer, women have a shorter healthspan than men, meaning they have a lower quality of life due to age-related illnesses.

Do women live longer than men?

Yes, women do tend to outlive men. On average, global research shows that women live about 5.4 years longer than men. In the United States, women live to an average age of 80 while men live to an average age of 75, according to the Centers for Disease Control.

Even more fascinating: This effect, which researchers call the “female survival advantage,” is seen across different countries. Even in cultures with vastly different histories and societies, women generally live longer.

What are some biological reasons women live longer than men?

Researchers have many hypotheses about women’s longer lifespan, and the longevity gap is likely due to a combination of many factors working together. There’s a ton of variation out there, so these are only the statistical trends across populations.

1. Sex chromosomes: Women have a lower risk of genetic mutations.

One of the leading hypotheses concerns sex chromosomes. Females (of all mammal species) carry two X chromosomes, while males have one X and one Y chromosome. In females, only one X chromosome is expressed in each cell; the other is inactivated. So about half of her cells express her father’s X chromosome and half express her mother’s.

Why does this matter? Because males have only one X chromosome, if that chromosome carries a harmful mutation, it gets expressed in every cell. For females, though, whether the mutation gets expressed depends upon whether it is recessive or dominant, and whether she inherited the same mutation from both parents. This explains why there are plenty of X-linked disorders that are more prevalent in men, such

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ADHD is typically associated with symptoms like impulsivity, hyperactivity, and trouble with focus. But a recent review of studies strengthens our understanding that kids with ADHD may also struggle with motor skills. These are the skills that let people move, control, and coordinate movements in the body.

Understood shares what you need to know and how you can help your child.

What the study found

This review of studies was published in the Journal of Autism and Developmental Disorders in September. It reviewed 25 studies that included kids with ADHD and kids without.

Combined, the 25 studies included over 2,000 children between the ages of 5 and 14 years. Almost half of the children had ADHD, and the rest did not. It’s the first time a review compared motor skills in kids with ADHD and neurotypical children. This comparison allows us to better understand the unmet needs of kids with ADHD.

When researchers reviewed all the studies, they found that children with ADHD were more likely to have lower motor competence than their neurotypical peers. Motor competence is the ability to perform different motor skills effectively and efficiently.

The researchers found that kids with ADHD had a particularly hard time with certain motor skills. These included:

• Fine motor control: Fine motor skills involve using the hands and fingers to make small movements.
• Manual dexterity: Manual dexterity is a type of fine motor skill used for gripping and moving objects with your hands.
• Manual coordination: Similarly, manual coordination is the ability to use the hands and fingers effectively, along with hand-eye coordination.
• Body coordination: Body coordination includes gross motor skills like running and jumping. It also includes balance, hand-eye coordination, and being able to use both sides of the body together.
• Locomotor skills: These skills allow you to move your body from place to place, such as running, jumping, or leaping.
• Throwing and catching: The ability to throw and catch involves hand-eye coordination and other motor skills.

The researchers suggest that difficulties with these skills may be due in part to issues with motor planning. Motor planning is a skill that requires coordinating all the steps it takes to complete a physical task. Motor planning and coordination require executive function to complete. Executive function is the brain’s ability to plan, focus, remember instructions, and manage tasks to reach goals. These skills are frequently affected by ADHD.

Other research has come to similar conclusions. Researchers estimate that up to 50% of childr

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Artificial intelligence in the workplace offers compelling benefits, such as faster execution, increased output, and better-informed decision-making. However, as organizations rush to implement AI, they often discover that speed and efficiency alone don’t translate into effective outcomes. Without the right guardrails and processes in place, overreliance on technology can introduce AI slop, which undermines productivity, trust, and quality.

In this article, Upwork, an online marketplace for hiring skilled freelancers, explains what AI slop is, the hidden costs of limited oversight, and how to maintain both productivity and quality while incorporating AI into your business.

What Is AI slop?

AI slop is output generated by artificial intelligence that seems adequate on the surface but falls short in substance. Outputs may include reports, presentations, messages, or code that appear grammatically correct and formatted properly but are missing depth, context, accuracy, or relevance. The end result is often content that creates more work than it saves.

Because AI outputs can seem accurate and look complete, they’re often accepted without adequate review. AI slop typically emerges when users don’t fully understand the limits of the tools they’re using, fail to apply appropriate oversight, or lack subject matter expertise. Unfortunately, this can mean passing along work that is flawed, vague, or simply wrong.

The hidden costs of AI slop

The effects of AI slop can compound quickly. At first glance, AI slop may seem like a minor inconvenience. But recent data shows that consequences are significant and widespread.

Low-quality work and reputational damage

Researchers from Stanford Social Media Lab and BetterUp Labs explored in September 2025 the implications of AI slop and coined the term “workslop” to describe the issue. Based on a survey of 1,000 full-time U.S. office workers, the research found that nearly 40% of respondents reported receiving some form of workslop — incomplete, low-quality content — in the previous month. Respondents estimated that more than 15% of the content they receive at work qualifies as workslop.

Put into perspective, this means that nearly one in six messages, deliverables, or reports may be unfinished, unclear, or require additional edits and cleanup before they can be used.

The emotional and reputational impacts can be significant. The research found that over half (53%) of the respondents say they feel annoyed, 38% feel confused, and 22% even feel offended when they encounter workslop. About half of the respondents said they view colleagues who send workslop as less capable, less reliable, and less creative. Additionally, 42% perceive those coworkers as less trustworthy, while 37% see them as less intelligent.

Burnout and lack of clarity

Even when productivity appears to be improving on paper, other implications o