By Deblina Chakraborty, Ashley Strickland, CNN
(CNN) — Before four Artemis II astronauts strapped into their Orion capsule to soar toward the moon, a tiny bit of each of them was already on board.
Incubated in a small triangular container stowed on the spacecraft just before launch were four USB-size “avatars,” which rode along with the history-making moon mission. But in many ways, their journey is just beginning.
Known as organ chips, the avatar crewmates are made with bone marrow tissue derived from cells donated by their full-size counterparts — NASA’s Reid Wiseman, Victor Glover and Christina Koch, and Canadian Space Agency astronaut Jeremy Hansen — and researchers believe the experiment could soon unlock unprecedented insights about the effects of space on human health.
The AVATAR, or A Virtual Astronaut Tissue Analog Response, study essentially allows scientists to simulate what happens to astronauts’ organs in deep space.
It offers a more granular look at where and when changes in the body begin, compared to traditional post-flight medical testing, according to Lisa Carnell, Director of NASA’s Biological and Physical Sciences Division. “We’ve never done this before,” she said.
Because researchers chose to focus on bone marrow for this organ chip experiment, Carnell expects to gather data on the crew’s immune responses to traveling through the deep space and the higher-radiation levels associated with such endeavors. Those insights could lead to individualized treatments that ease the way for the astronauts to embark on longer missions — perhaps deeper into the cosmos.
“When we send these alongside Christina, Victor, Reid, Jeremy, they all may respond different to the deep space radiation environment. Somebody may be radio resistant and will learn something new, and you know, or maybe somebody is more extremely susceptible to radiation,” Carnell said before the mission began. “Well, now we can tailor medical kits that we can make personal lives for them on their journey. They go to Mars, they go to the moon, to live for long duration. We can send the right therapeutics with them to make sure they stay healthy and that they can thrive in those environments.”
The goal, Carnell said, is to one day be able to send up avatars of astronauts selected for deep space and long-duration missions ahead of time, so crews can prepare for potential health concerns before they become an issue far from home.
“In the Apollo days, it was just a few days on the surface. If we’re literally going to have people on the surface for a long period of time, even 30 days or longer, I mean, we don’t have data on that at all, right?” Carnell said. “We like to say, ‘Know before we go.’ It’s that simple. Like, how do we know before we send them to ensure that we bring them back healthy and that they’re as safe as can be? And this is such a simple … eloquent way to do that.”
As AVATAR quietly careens along in a corner of the spacecraft, the Artemis II astronauts are also actively working to collect data that could inform the future of human spaceflight — and that job doesn’t end once they splashdown.
The 5 hazards of space travel
Space is a stressful place for the human body, said Dr. Steven Platts, chief scientist for human research at NASA’s Johnson Space Center in Houston.
The agency has an acronym for the overarching hazards that humans face in space: RIDGE, which stands for radiation, isolation, distance from Earth, gravity (or the lack thereof) and environment (which can be hostile both inside and outside of the spacecraft), Platts said.
Any time humans venture to space, but especially on the rare occasion that they journey beyond Earth orbit, researchers want to monitor as much as they can about the effects of the harsh environment on the body — even if it’s just for 10 days.
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