By Max Saltman, Paula Newton, CNN

(CNN) — Police in Toronto are investigating a “national security incident” after a shots were fired at the US consulate early Tuesday, leaving damage to the building but no injuries.

Police said a witness flagged a constable down to report gunshots at the consulate around 5:29 a.m., roughly an hour after investigators believe the shooting occurred.

Deputy Chief Frank Barretto of the Toronto Police Service said that authorities “found evidence of a firearm discharge, shell casings as well as damage to the building.”

Witness evidence shows that two male suspects fired what appears to be a handgun at the front of the consulate before fleeing in a white Honda CRV, Barretto said. Police later released an image of the car taken from security camera footage.

“There were people inside the building,” Barretto said. “However, this building is highly secure, highly fortified, and there were no injuries.”

The deputy chief later said that the building is so heavily encased in metal and glass that the staff within may not have noticed the gunfire at all.

“This is very early in the investigation,” Baretto said. “It is very active, and we are aggressively assigning investigational resources to determine what happened and to bring the offenders to justice.”

Toronto’s Integrated Gun and Gang Task Force is leading the investigation, he added, with help from other local and federal agencies.

American embassies and consulates have increased security and recalled employees all over the world as the US and Israeli war against Iran continues to expand.

The shooting in Toronto comes days after a bombing at the US Embassy in Oslo, Norway. US diplomatic missions recently have been targeted in Iranian retaliatory strikes in the Persian Gulf.

Asked if the incident was linked to the ongoing war in the Middle East, Royal Canadian Mounted Police (RCMP) Chief Superintendent Chris Leather said that it is too early to say, but any connection between the incident and current events is under investigation.

“At this time, the INSET team has been engaged as this is a national security incident,” Leather said, referring to the Canada’s Integrated National Security Enforcement Teams, which handle counter-terrorism, “and we are working with Toronto Police and others to understand the motivations of those involved.”

Leather added that Ontario has seen multiple shootings at synagogues in recent days, which “very much factors into how we will approach this matter, as well.”

Ontario Premier Doug Ford speculated at a separate press conference that the synagogue shooting and incident at the consulate could be the work of “sleeper cells.”

“This is just me speaking,” Ford said. “I believe there are sleeper cells all over the world, as we know – they’re in the US, they’re in Canada.”

Leather told reporters that the RCMP does not have “any information to provide at this time on any sleeper cells that may or may not exist in Canada.”

Whether the shooting will be classified as terrorism or not, Leather said, depends upon the results of the investigation.

“It’s definitely a national security incident, because we had the US Consulate, after all, struck by gunfire,” Leather said.

US Ambassador to Canada Pete Hoekstra

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By Gloria Pazmino, John Miller, CNN

(CNN) — Police have found a suspicious package in the area around Carl Shurz Park in upper Manhattan, near Gracie Mansion, a law enforcement official briefed on the situation tells CNN.

A New York City Parks Department worker flagged the item, another official added.

The area has been blocked off and people have been evacuated from the park while police investigate.

This is a developing story and will be updated.

The-CNN-Wire
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CNN

By Brenda Goodman, CNN

(CNN) — The prescription drug leucovorin is getting a label update, but it’s not what that the US Food and Drug Administration suggested during a White House briefing in September, when officials touted the drug as a potential treatment for thousands of children with autism.

On Tuesday, the FDA approved the high-dose B vitamin — a treatment long used to counteract the side effects of chemotherapy — for cerebral folate deficiency in the receptor 1 gene, a genetic condition that’s estimated to affect only about 1 in 1 million people. Fewer than 50 cases have ever been identified worldwide. FDA Commissioner Dr. Marty Makary called Tuesday’s approval “a significant milestone” for patients with the condition.

But in September, Makary and US Health and Human Services Secretary Robert F. Kennedy Jr. indicated that the drug would be available to help many more children. Standing alongside President Donald Trump at a White House briefing, Kennedy said they had “identified an exciting therapy that may benefit large numbers of children who suffer from autism.”

The update on leucovorin may hit some families of children with autism especially hard. At the September briefing — when Trump made unsupported claims about the painkiller Tylenol as a cause of autism and cautioned parents about getting too many vaccines for their kids — the president said changing the label on leucovorin “gives hope to the many parents with autistic children that it may be possible to improve their lives.”

In the months since, leucovorin prescriptions surged, making the drug hard to find.

Drug approved for rare condition, not autism

With cerebral folate deficiency in the receptor 1 gene, a defect causes proteins that guide folate into the brain to malfunction. The result is normal levels of folate in the blood but not in the brain and nervous system, where it’s important for thinking, speech and movement.

In an op/ed published in Politico and reposted on the White House website last fall, Makary said his agency would “approve prescription leucovorin as a treatment for children with cerebral folate deficiency and autistic symptoms.”

Makary said in the televised briefing that between 20% and 50% of children with autism might make antibodies that block the proteins that help ferry folate into their brains – meaning some of the more severe symptoms of autism might be caused by an autoimmune condition.

Although he noted that leucovorin was not a cure for autism, Makary highlighted small studies showing that among children with folate deficiency and autism, it could improve speech for roughly 60%.

The Trump administration was making a bold move to expand the use of the drug, “opening the door to the f

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