By Jacqueline Howard, CNN

(CNN) — Emily Padgett has spent months trying to get her hands on estrogen patches, bouncing between pharmacies, transferring prescriptions and switching brands three times.

For a couple of anxious weeks in January, she had to go without them entirely.

“There’s definitely some symptoms that I noticed popping back after I went off of the patch for a while, and they still haven’t completely gone away since then,” said Padgett, who is in perimenopause.

After a long stretch of uncertainty, she is now finally able to access estrogen patches at a small independent pharmacy in her neighborhood. But each time she walks up to the counter to refill her prescription, she worries about hearing those three words she’s come to fear: “Out of stock.”

For many women in the United States who encounter drenching night sweats, sudden hot flashes, debilitating exhaustion and other menopause-related symptoms, small estradiol patches have become a steady source of relief.

That relief is becoming harder to find – and doctors brace themselves for potentially more shortages to come.

Manufacturers point to a rise in demand, driven by a greater awareness of menopause care and recent action by federal regulators to clarify the risks versus benefits of hormone therapies.

The estradiol patch, a tiny square worn on the skin, may be discreet, but its impact is powerful. It delivers a consistent stream of estrogen to the body, which gets absorbed through the skin. The estrogen hormone naturally declines with age and when levels drop during menopause, symptoms can surge. During perimenopause, the transitional period before menopause, levels of estrogen can start to decrease.

Padgett, a 49-year-old mother of two in Atlanta, said that she had to go those two weeks in January without medication because she could not find a pharmacy that had estrogen patches in stock.

“It’s just an inconvenience more than anything,” Padgett said.

Her perimenopause symptoms of irritability, insomnia and brain fog came back during that time, and she thinks they were exacerbated by the stress of the estrogen patch shortage.

“I was definitely stressed about not getting them, and so my main symptoms were irritability and waking up in the middle of the night stressed and not sleeping,” she said. “I feel like my symptoms have still not completely gone away.”

After switching from different CVS locations and Amazon to the neighborhood pharmacy that ultimately came through, Padgett said that she is back to her regular routine of applying a twice-weekly estrogen patch – but it is a different brand than she is used to.

“I’m on my third different brand now,” she said, and she still worries about future supply.

Estrogen supply challenges

Estrogen patches are available through a doctor’s prescription only. But lately, some prescriptions are taking longer to fill as supplies run low.

“Manufacturers have been unable to provide sufficient supply of hormone replacement therapies (HRT) over the last several weeks,” CVS spokesperson Amy Thibault said in an email. “When these manufacturer supply interruptions occur, our pharmacy teams make every effort to ensure p

CNN

From CNN en Español’s Gonzalo Zegarra and Rocío Muñoz-Ledo

(CNN) — Nemesio “El Mencho” Oseguera Cervantes was a feared Mexican drug lord and the leader of a ruthless cartel accused of masterminding efforts to push fentanyl into the United States.

Once a police officer, Oseguera went on to become one of the world’s most wanted fugitives, with the United States alone offering a $15 million bounty for information leading to his arrest.

Oseguera, who formed and led the Jalisco New Generation Cartel (CJNG), was an elusive figure who had been considered Mexico’s most powerful cartel boss since Sinaloa kingpin Joaquín “El Chapo” Guzmán was arrested last decade.

Born in July 1966 in the western state of Michoacán, Oseguera later moved to the US and was deeply involved in drug trafficking from the 1990s, according to the US Drug Enforcement Administration (DEA). In 1994, he was convicted in California for conspiracy to distribute heroin and served three years in a US prison.

After he returned to Mexico, he worked as a police officer in the western state of Jalisco but soon resumed his criminal activities, building his influence in the shadowy world of narcotics and rising to become the head of one of the country’s most powerful and ruthless criminal empires.

Wanted by authorities in Mexico and the US, Oseguera or “El Mencho” kept a low profile – so much so that only a handful of photographs of him exist.

His death on Sunday in a Mexican military operation in Tapalpa, in the western coastal state of Jalisco, has triggered widespread unrest across parts of the country.

On the most-wanted list

Oseguera had a long career in brutality before forming CJNG. For a time, he served as chief of hitmen, or key enforcer, for the Milenio Cartel, before overseeing security and operational violence for the famed Sinaloa Cartel, whose former leader Guzmán is serving a life sentence in a US prison.

According to the DEA, CJNG emerged in the 2010s from the remnants of the Milenio Cartel, which splintered amid a power vacuum after its leader Óscar Nava Valencia was captured in 2009.

Oseguera built the group with Abigael González Valencia, leader of Los Cuinis – a family-based cartel operating in Michoacán, which served as the financial and logistical arm of CJNG and oversaw its “diverse network of money laundering operations,” according to the DEA.

But it was only through marriage to Abigael’s sister, Rosalinda González Valencia, that Oseguera gained real influence in the new entity.

“In reality, El Mencho reached the cartel’s leadership through a strategy of diplomacy via marriage,” public security analyst David Saucedo told CNN en Español. “He was indeed the chief of hitmen for ‘Nacho’ Coronel (a Sinaloa Cartel leader), but he lacked the lineage that Rosalinda, his wife, possessed,” Saucedo added.

The burgeoning cartel quickly grew its sphere of influence to claim a significant presence across Mexico and became a key pla

Por Lex Harvey, CNN

El Gobierno de EE.UU. instó a los estadounidenses que se encuentran en varios estados mexicanos, incluidos lugares de vacaciones populares en Jalisco, Baja California y Quintana Roo, a refugiarse en sus alojamientos luego de que estallara la violencia estalló en todo el país tras la muerte del líder narco Nemesio Oseguera Cervantes, alías El Mencho.

Si bien los aeropuertos están operando con normalidad, algunos vuelos nacionales e internacionales han sido cancelados en las ciudades de Guadalajara y Puerto Vallarta, en el occidente de México.

Adryan Moorefield, residente de Dallas, tenía previsto viajar a su casa desde Puerto Vallarta el domingo, pero se despertó con la noticia de que miembros de grupos del crimen organizado habían incendiado autobuses, bloqueado carreteras y se habían enfrentado con las autoridades.

“Fue una sorpresa total, casi como estar en la dimensión desconocida”, le dijo Moorefield a CNN. “Ya habíamos estado en Puerto Vallarta y pensamos que este sería el lugar ideal para unas vacaciones de playa rápidas y fáciles”.

El turista estadounidense Jim Beck le dijo a CNN que se aventuró a salir de su hotel en Puerto Vallarta para desayunar el domingo y vio “taxis explotando por toda la ciudad, que bloqueaban las carreteras”.

“Inmediatamente, todos corrieron por la calle, gritando y vociferando, y les dijeron a todos que regresaran a sus hoteles”, dijo Beck.

Desde entonces ha estado encerrado en su hotel, esperando instrucciones sobre cuándo podría ser seguro salir.

Mari, otra turista que pidió que solo la identificáramos por su nombre de pila por razones de privacidad, dijo que su joven familia ha estado refugiada en su propiedad de vacaciones y observando cómo se desarrollan los disturbios afuera.

“Tenemos dos niños pequeños y da mucho miedo”, dijo. “Toda la bahía estaba envuelta en llamas”, añadió. “Durante horas, solo había una columna de humo flotando. No se podía ver nada al otro lado”.

Si actualmente te encuentras en las zonas de México afectadas, esto es lo que debes hacer, según la orientación del Departamento de Estado de EE.UU.:

• Busca refugio y minimiza los desplazamientos innecesarios. Permanece en tus residencias u hoteles.
• Evita las áreas cercanas a la actividad policial.
• Mantente consciente de tu entorno.
• Monitorea los medios locales para obtener actualizaciones.
• Sigue las instrucciones de las autoridades locales y, en caso de emergencia, llama al 911.
• Evita las multitudes.
• Mantén a sus familiares y amigos informados de su ubicación y bienestar por teléfono, mensajes de texto y redes sociales.

Cualquier persona que necesite ayuda puede comunicarse con estos números:

Desde EE.UU. y Canadá: 1-888-407-4747

Desde el extranjero (incluido México): +1 202-501-4444

The-CNN-Wire
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The post ¿Qué puedes hacer si estás varado en México? appeared first on News Channel 3-12.

By Alexandra Banner, CNN

An armed man was shot and killed after breaching the secure perimeter of President Donald Trump’s Mar-a-Lago residence on Sunday. Neither Trump nor the first lady was present at the time of the incident, and no one else on the estate was harmed.

Here’s what else you need to know to get up to speed and on with your day.

1⃣ Mexico violence

Mexico’s most-wanted cartel boss and head of the Jalisco New Generation Cartel, Nemesio “El Mencho” Oseguera Cervantes, was killed Sunday in a Mexican military operation in the town of Tapalpa. His death sparked widespread unrest, with suspected gang members torching buses and businesses while clashing with security forces. The US State Department urged American nationals in parts of Mexico to stay indoors until further notice as several other countries issued similar advisories to their citizens. The White House said the US provided intelligence support for the operation, part of ongoing efforts to put pressure on Mexico to curb drug trafficking.

ADVICE: What to do if you’re stranded in Mexico

2⃣ Winter storm

A powerful winter storm is slamming the northeastern US, bringing heavy snow to areas from Virginia to Maine and putting more than 40 million people under blizzard warnings. Places hardest hit could see up to two feet of snow, with more than a foot expected in Philadelphia, New York and Boston — the most seen in years for some. The treacherous conditions have made travel nearly impossible, prompting thousands of flight cancellations and widespread public transit shutdowns. New York City has also enacted a citywide travel ban until at least noon and canceled schools today, its first proper snow day since 2019.

3⃣ TSA PreCheck

The Department of Homeland Security has reversed its decision to suspend the TSA’s PreCheck program after initially causing confusion on Sunday by announcing a temporary halt. DHS initially said that PreCheck, along with the Global Entry program, would close at 6 a.m. ET due to the ongoing partial government shutdown. The agency later clarified in a statement that it “will evaluate on a case-by-case basis and adjust operations.” Analysts say a potential PreCheck suspension would affect millions of flyers by effectively dismantling expedited security lanes and fast‑track customs processing.

4⃣ Olympics conclude

The 2026 Winter Olympics came to an end on Sunday with a grand closing ceremony in Verona, Italy. At the end of the show, the baton was passed to France, which will host the next Winter Games in 2030. This year, Norway — the most decorated country in Winter Olympics history — once again led the medal count with 41 overall, including 18 gold. Cross-country skier Johannes Høsflot Klæbo topped the charts, becoming the first athlete

Por CNN en Español

Liberan a decenas de presos políticos en Venezuela tras la ley de amnistía. Una bomba ciclónica de alto impacto azota al noreste de Estados Unidos. Ucrania enfrenta una “catástrofe” demográfica. Esto es lo que debes saber para comenzar el día. Primero la verdad.

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Nemesio Oseguera Cervantes, alias el Mencho, líder del Cartel Jalisco Nueva Generación (CJNG), murió el domingo en un operativo encabezado por militares en Tapalpa, informó la Secretaría de Defensa Nacional de México. Tras conocerse su muerte hubo bloqueos y alteración del orden público en múltiples lugares del país. Sigue aquí el minuto a minuto de la información.

• Minuto a minuto: los detalles del operativo militar en el que fue abatido el Mencho
• ¿Quién era El Mencho, el expolicía que avanzó en el crimen hasta liderar uno de los carteles más violentos de México?

Al menos 40 liberaciones de presos políticos han sido confirmadas tras la promulgación de la ley de amnistía la semana pasada en Venezuela, informó el domingo la ONG Foro Penal. La Cruz Roja Venezolana anunció que atenderá a los liberados, mientras que familiares de presos políticos informaron que más de 200 detenidos en la cárcel El Rodeo I comenzaron una huelga de hambre para pedir sus liberaciones.

Una bomba ciclónica de alto impacto azota al noreste de Estados Unidos, provocando fuertes nevadas en zonas desde Virginia hasta Maine. Hay más de 40 millones de personas bajo alerta de ventisca, y se espera que caigan más de 30 centímetros de nieve en Filadelfia, Nueva York y Boston. Sigue aquí el minuto a minuto de la información.

• Zohran Mamdani prohíbe viajes por Nueva York debido a la tormenta de nieve

A medida que la guerra en Ucrania entra en su cuarto año, la tasa de natalidad del país se desploma, con un número creciente de personas que tienen problemas de fertilidad o posponen la decisión de tener hijos. Al mismo tiempo, las pérdidas en el frente aumentan y millones de personas que huyeron como refugiados ahora se han asentado en el e